The NSW Systems Biology Initiative (SBI) is an exciting new initiative which aims to develop systems-level views of the molecular biology of the cell. The SBI undertakes basic and applied bioinformatics research in proteomics, genomics and systems biology and is funded to engage in collaborative projects with other groups in these areas. Collaborative projects are in association with users of the major -omics facilities in NSW including the Ramaciotti Centre for Gene Function Analysis, the Australian Proteome Analysis Facility, the UNSW Bioanalytical Mass Spectrometry Facility and the Southern Cross University Centre for Plant Conservation Genetics.
For further information please contact:
Professor Marc Wilkins
NSW Systems Biology Initiative
The School of Biotechnology and Biomolecular Sciences
University of New South Wales
marc.wilkins@unsw.edu.au
The Peter Wills Bioinformatics Centre was established at Garvan in 2001. Its goal is to apply techniques derived from disciplines such as applied mathematics, statistics and computer science to understand, organise and analyse biological data. Briefly, some of the services that the PWBC offer include:
- Experimental design.
- Comprehensive quality control (QC) assessment of your data.
- Pre-processing data, normalisation and summarisation of gene expression at the transcript, or gene level to facilitate the comparison of your experimental groups.
- We are currently investigating methods to extract information at the exon level, from the data on Affymetrix Gene arrays, which will facilitate alternative splicing analyses.
- Differential expression analysis, both for simple two-group comparison style of experiments, and more complex multi-time-point/treatment style of experiments.
- Interpretation of differentially expressed genes in a biological context, including Gene Ontology, and pathway over-representation analyses, and gene set enrichment analysis (GSEA).
- Clustering analysis.
- Analysing your data in a similar style to that of previously published journal articles, whose analysis you may be interested in replicating under your own experimental conditions.
- Completely custom analysis.
For further information please contact:
Dr Warren Kaplan and Mark Cowley
Peter Wills Bioinformatics Centre
The Garvan Institute of Medical Research
pwbc@garvan.org.au
